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DuPont Fluorochemicals confirmed that HFO-1234yf can be used safely as an automotive refrigerant. The product has a low global warming potential, and it meets both ISO and SAE ICCC safety guidelines for employing refrigerants. HFO-1234yf was developed in response to Europe's Mobile Air Conditioning Directive. The refrigerant enables energy efficiency and balances safety, performance, sustainability and cost.